Supplier: AUREL PHARMACEUTICALS
Contact person: Mr. SUMIT GUPTA
Position: OWNER
Address: DELHI
Country: India
Phone: 22437760 - Mobi: 9811278800
ERLONAT 150mg
Price:
INDIAN - TARCEVA 150mg (30 tablets)
Each film coated tablet contains Erlotinib Hydrochloride equivalent to Erlotinib 150mg.
It is used to treat non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer.
The drug follows Geftinat (Gefitinib), which was the first drug of this type. Erlotinib specifically targets the epidermal growth factor receptor (EGFR) tyrosine kinase, which is highly expressed and occasionally mutated in various forms of cancer. It binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. By inhibiting the ATP, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.
Each film coated tablet contains Erlotinib Hydrochloride equivalent to Erlotinib 150mg.
It is used to treat non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer.
The drug follows Geftinat (Gefitinib), which was the first drug of this type. Erlotinib specifically targets the epidermal growth factor receptor (EGFR) tyrosine kinase, which is highly expressed and occasionally mutated in various forms of cancer. It binds in a reversible fashion to the adenosine triphosphate (ATP) binding site of the receptor. For the signal to be transmitted, two EGFR molecules need to come together to form a homodimer. These then use the molecule of ATP to trans-phosphorylate each other on tyrosine residues, which generates phosphotyrosine residues, recruiting the phosphotyrosine-binding proteins to EGFR to assemble protein complexes that transduce signal cascades to the nucleus or activate other cellular biochemical processes. By inhibiting the ATP, formation of phosphotyrosine residues in EGFR is not possible and the signal cascades are not initiated.
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